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A multi-center study in order to further define the molecular basis of beta-thalassemia in Thailand, Pakistan, Sri Lanka, Mauritius, Syria, and India, and to develop a simple molecular diagnostic strategy by amplification refractory mutation system-polymerase chain reaction.

Molecular cloning of the breakpoints of the hereditary persistence of fetal hemoglobin type-6 (HPFH-6) deletion and sequence analysis of the novel juxtaposed region from the 3' end of the beta-globin gene cluster.

A role for the alpha 113 (GH1) amino acid residue in the polymerization of sickle hemoglobin.

Interaction of two different disorders in the beta-globin gene cluster associated with an increased hemoglobin F production: a novel deletion type of (G) gamma ((A) gamma delta beta)(0)-thalassemia and a delta(0)-hereditary persistence of fetal hemoglobin determinant.(Alpha)alpha 5.3: a novel alpha( )-thalassemia deletion with the breakpoints in the alpha 2-globin gene and in close proximity to an Alu family repeat between the psi alpha 2- and psi alpha 1-globin genes.

The alpha-globin gene adjacent to the gene for Hb Q-alpha 74 Asp replaced by His is deleted, but not that adjacent to the gene for Hb G-alpha 30 Glu replaced by Gln; three-fourths of the alpha-globin genes are deleted in Hb Q-alpha-thalassemia.

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